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✔️ Uses of
✔️ How does
✔️ Side Effects of
Common side effects include abdominal pain, anemia, blurred vision, headache, chest pain, nausea, and diarrhea.
✔️ Quick Suggestions:
✔️ Indication:
Voriconazole is recommended for the treatment of the following fungal infections in individuals aged 12 and up:
- Invasive Aspergillosis
- Candidemia (non-tuberculous) and widespread candidiasis in the skin, abdomen, kidneys, bladder wall, and wounds
- Candida esophagitis
- Infections caused by Scedosporium apiospermum and Fusarium species, especially Fusarium solani, in patients resistant to or intolerant of alternative treatments.
✔️ Pharmacology
Voriconazole is a triazole antifungal drug that inhibits CYP450-dependent 14-alpha sterol demethylase, binding to and inhibiting ergosterol production. Inhibition of 14-alpha sterol demethylase leads to ergosterol depletion in fungal cell membranes.
✔️ Dosage & Administration:
Oral:
- Loading dose regimen (for the first 24 hours):
- At or over 40 kg body weight: 400 mg or 10 ml every 12 hours
- Below 40 kg body weight: 200 mg or 5 ml every 12 hours
- Maintenance dose (after first 24 hours):
- At or over 40 kg body weight: 200 mg or 5 ml twice daily
- Below 40 kg body weight: 100 mg or 2.5 ml twice daily
✔️ Interaction
- Voriconazole interacts with CYP3A4, CYP2C9, and CYP2C19 inhibitors and inducers. Dosage adjustments are necessary.
- It may increase concentrations and activity of drugs metabolized by CYP3A4, CYP2C9, and CYP2C19.
✔️ Contraindications
- Known hypersensitivity to Voriconazole or any other components.
- Co-administration with certain drugs due to the risk of serious adverse reactions.
✔️ Pregnancy & Lactation
Use during pregnancy is considered only if the potential benefit outweighs the risk to the fetus. Limited data are available. Caution is advised during lactation.
✔️ Precaution & Warnings:
Long-term exposure beyond 180 days requires careful consideration due to the association with squamous cell carcinoma of the skin (SCC).
✔️ Storage Conditions
Store below 25°C, and protect from light and moisture. Keep out of children's reach.
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